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متن کامل


نویسنده: 

رجبی فاطمه

اطلاعات دوره: 
  • سال: 

    1394
  • دوره: 

    32
تعامل: 
  • بازدید: 

    2671
  • دانلود: 

    1232
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اطلاعات دوره: 
  • سال: 

    1384
  • دوره: 

    8
  • شماره: 

    5 (پیاپی 33)
  • صفحات: 

    353-357
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    18835
  • دانلود: 

    368
چکیده: 

زمینه و هدف: (FDE) Fixed drug eruption یکی از انواع بثورات دارویی است که سبب ابتلای پوست یا مخاط می شود و پس از مصرف مجدد دارو در همان محل (محل های) قبلی عود می کند. این مطالعه با هدف تعیین ویژگی های بالینی و عوامل ایجاد کننده FDE صورت گرفت.روش اجرا: این مطالعه توصیفی case-series روی یک صد بیمار مبتلا به FDE صورت گرفت که به درمانگاه سرپایی پوست بیمارستان حضرت رسول اکرم (ص) تهران در عرض مدت شش سال مراجعه کرده بودند. تشخیص اولیه FDE بر اساس یافته های بالینی انجام می شد که پس از بهبود کامل ضایعه اولیه با باقی ماندن پیگمانتاسیون قهوه ای رنگ در پوست همراه بود. برای تایید تشخیص، از تست تشخیصی challenge test به شکل مصرف خوراکی دوز واحد از داروی مورد نظر با مقدار کم استفاده شد که با ظهور مجدد ضایعه در مکان قبلی همراه بود.یافته ها: بیش ترین موارد ناشی از حساسیت به داروهای کوتریموکسازول و کدیین بود که 88% و 3% را شامل می شد. شایع ترین محل بروز FDE در بیماران مذکر، ناحیه گلنس آلت تناسلی و در بیماران مونث پوست تنه و قفسه سینه بود که به ترتیب در 57.7% افراد مذکر و 48.3% افراد مونث مورد مطالعه دیده شد. در یک مورد از بیماران، حساسیت به چند دارو به شکل حساسیت به کوتریموکسازول، کدئین و تتراسیکلین مشاهده شد که پس از بهبود ضایعه های اولیه مجددا با تجویز انفرادی هر کدام از سه دارو، ضایعه ها در همان محل اولیه بروز کردند. بسیاری از بیماران به طور هم زمان داروی استامینوفن هم مصرف می کردند ولی موردی از حساسیت به این دارو اثبات نشد.نتیجه گیری: کوتریموکسازول شایع ترین داروی عامل FDE است.

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نویسندگان: 

نشریه: 

THERANOSTICS

اطلاعات دوره: 
  • سال: 

    2020
  • دوره: 

    10
  • شماره: 

    3
  • صفحات: 

    1355-1372
تعامل: 
  • استنادات: 

    2
  • بازدید: 

    61
  • دانلود: 

    0
کلیدواژه: 
چکیده: 

شاخص‌های تعامل:   مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
نویسندگان: 

اطلاعات دوره: 
  • سال: 

    2023
  • دوره: 

    198
  • شماره: 

    -
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    1
  • بازدید: 

    2
  • دانلود: 

    0
کلیدواژه: 
چکیده: 

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اطلاعات دوره: 
  • سال: 

    2022
  • دوره: 

    8
تعامل: 
  • بازدید: 

    173
  • دانلود: 

    0
چکیده: 

Recent studies have been indicating that many clinical drug combinations surpass single-drug therapy efficacy. Machine learning, deep learning, network analysis, and search algorithms have been considered to facilitate the discovery of synergistic drug combinations, and two of the best state-of-the-art models in this area are under the deep learning category. In this paper, we present DComG, a Graph Auto Encoder method to predict synergistic drug combinations. Using the dataset provided in DCDB, our analysis shows tremendous improvement in the performance of predicting new drug combinations over previously introduced state-of-the-art models by an average of 4% in ROC_AUC scores. We highlight the importance of drug-drug interactions (DDI) in the form of node2vec features of DComG graph inputs for predicting new drug combinations. Finally, we address the results of our model in terms of biological interpretations of drug combinations based on recent medical drug combination papers in the literature.

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اطلاعات دوره: 
  • سال: 

    1396
  • دوره: 

    8
  • شماره: 

    2
  • صفحات: 

    201-208
تعامل: 
  • استنادات: 

    1
  • بازدید: 

    1600
  • دانلود: 

    2151
چکیده: 

سابقه و هدف: از آنجا که استراتژی طب سنتی تعریف شده ی سازمان بهداشت جهانی در سال های 2023-2014 بر تحقیقات گسترده تاکید دارد، یک حیطه ی اساسی بحث ساخت داروهای ترکیبی است که در قرابادین کبیر نیز بعنوان بهترین علوم بیان شده است. به کمک شناخت قواعد سنتی ترکیب داروها، می توان به ارایه ی سیستمی نوین در بحث داروهای ترکیبی رسید که در آن عوارض جانبی به حداقل ممکن رسد و اثربخشی افزایش یابد. لذا این مقاله ارائه گردید.مواد و روش ها: این تحقیق، مطالعه ای مروری است که در آن اصول ترکیب مفردات در ساخت داروهای ترکیبی سنتی ایرانی و چینی به صورت جداگانه، بیان شده و وجه تشابه یا تفاوت آن ها تحلیل شده است. برای بخش سنتی ایرانی از کتاب قرابادین کبیر عقیلی و بخش سنتی چینی، از کتاب(Chinese herbal formulas treatment principles and composition strategies)  و (Systems biology for herbal medicine) استفاده شد و مقالات مرتبط در پایگاه های اطلاعاتی Google Scholar، Sciencedirect، Scopus، Pubmed، nature،  embaseبا کلیدواژه های (complex herbal products in traditional medicine)، (combination of herbs, composition strategy of herbal formula) در زمان اردیبهشت ماه 94 جستجو شد.یافته ها: طب سنتی ایرانی و چینی با وجود تفاوت ها در مبانی پایه ای فکری، از نظر اصول فن ساخت داروهای ترکیبی مشابهت زیادی دارند و هر دو در بیان علل ترکیب اجزا به موارد مشابهی اشاره نموده اند از جمله اثر تاکید متقابل، متقابل افزاینده، متقابل خنثی کننده، سرکوب گر، آنتاگونیسم و اثر ناسازگار. مدل ساختاری فرمول های ترکیبی در طب سنتی ایرانی و چینی از نظر اصول مشابهند و شامل اجزای ماده موثره، معین، رساننده و مصلح عوارض جانبی می باشند.نتیجه گیری: دارودرمانی سنتی می تواند به دارودرمانی رایج کمک کند. با شناخت خواص سنتی اجزا و خاصیت کلی فرمولاسیون، با تحلیل جایگاه اجزای فرمول داروی ترکیبی بر اساس مدل ساختاری، می توان دامنه ای وسیع از تحقیقات بر اساس فارماکولوژی معکوس ایجاد نمود و به کمک آن به تفسیر بهتری از فلسفه ی ترکیب اجزا در فرآورده های سنتی پرداخت.

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مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
اطلاعات دوره: 
  • سال: 

    2023
  • دوره: 

    11
  • شماره: 

    3
  • صفحات: 

    417-427
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    27
  • دانلود: 

    0
چکیده: 

The search for effective treatments for complex diseases, while minimizing toxicity and side effects, has become crucial. However, identifying synergistic combinations of drugs is often a time-consuming and expensive process, relying on trial and error due to the vast search space involved. Addressing this issue, we present a deep learning framework in this study. Our framework utilizes a diverse set of features, including chemical structure, biomedical literature embedding, and biological network interaction data, to predict potential synergistic combinations. Additionally, we employ autoencoders and principal component analysis (PCA) for dimension reduction in sparse data. Through 10-fold cross-validation, we achieved an impressive 98 percent area under the curve (AUC), surpassing the performance of seven previous state-of-the-art approaches by an average of 8%.

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اطلاعات دوره: 
  • سال: 

    2023
  • دوره: 

    13
  • شماره: 

    2
  • صفحات: 

    1959-1969
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    32
  • دانلود: 

    0
چکیده: 

The result showed the maximum resistance for imipenem (100%), meropenem (100%), cefotaxime (98.6%), and ceftazidime (98.6%), and minimum resistance for tetracycline (65.7%) and gentamicin (68.6%). The MCBT test for meropenem-gentamicin-tetracycline antibiotics demonstrated 65.6% and 6.3% of MDR Acinetobacter baumannii strains killed at high and low concentrations of antibiotics, respectively (P=0.04). Besides, 34.4% and 93.8% of MDR Acinetobacter baumannii strains lived at high and low concentrations of meropenem-gentamicin-tetracycline antibiotics, respectively, which were statistically significant (P=0.04). There was a significant relationship between the MIC of gentamicin-meropenem in the combination (Checkerboard) (P=0.0001). Antibiotic interaction effects frequencies were 6.3%, 53.1%, and 40.6% for synergy, incremental, and indifference, respectively. In this study, a significant difference was shown between the FICIs of meropenem (0.68±0.27) and gentamicin (0.003±0.003) (P=0.0001). Also, there was a significant correlation between the FICI factor and the antibiotic's antimicrobial interaction by MCBT (r=0.95, P=0.0001).Conclusion: It seems that the combination of meropenem-gentamicin-tetracycline antibiotics had additive antibacterial effects and could be used to suppress MDR Acinetobacter baumannii isolated.

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نویسندگان: 

Faraji Hassan

اطلاعات دوره: 
  • سال: 

    1402
  • دوره: 

    13
  • شماره: 

    3
  • صفحات: 

    31-45
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    154
  • دانلود: 

    16
چکیده: 

A B S T R A C TFor choosing suitable place multiple methods are introduced, which examine the qualities, methods and patterns of location selection. The current methods use global approach and do not pay attention to spatial differences, environmental variation in variables, local changes modeled by local weighting indicators. It has been selected as a case study to evaluate the EMS center of Fars province and to evaluate the indicators of distance from the power plant, distance from logistics centers, industries, transportation terminals, hospitals, hotels and tourism, cities, rural areas and custom centers. has been used, using the AHP method to weight the qualities, and then for local weights, non-overlapping neighborhood filtering within a radius of 25 km are used and calculate the corresponding changes, quantity, ratio Presented in this article, the obtained weights, then the compute local weighted layers, and then local weight was multiplied in the normalized layers and the final layer were obtained. In the next step, it was combined and calculated to compare the data using the global method. The results of the two methods were transferred to the points of the EMS and the results were analyzedExtended AbstractIntroductionIn geographical studies and spatial planning, there are different approaches to choosing the right place for all kinds of applications and uses, and a process is followed to choose the best places. This process includes stating the research problem (cognition), choosing the criteria and preferences of decision makers and how to determine the weight of indicators, combining criteria (design) and finally, choosing the best option. In the current methods of spatial decision, the criteria are given a fixed weight, while in geographical locations, the distribution of geographical phenomena is not uniform. In this case, attention should be paid to the spatial distribution pattern of geographical phenomena based on the principle of sensitivity of the range of changes, the size of the range of changes affects the outputs, and the data with a smaller range of changes also have a lesser effect on the output. The data with a larger range of changes will have a more significant effect on the output. Therefore, in spatial analysis, indicators that have small changes are less important. Local models have been presented to model local changes in spatial multi-criteria decision-making; in this research, the main issue is how to model the local changes that affect the expected outputs. MethodologyThe research process is based on multi-criteria spatial decision-making methods (national and local). First, spatial patterns of indicators were analyzed through exploratory analyzes of ESDA spatial data. Then based on the review of the research criteria, the direct weighting method was used to calculate the weight of the indicators, and the experts were asked to specify the weight of the criteria in the range of 1 to 10. The opinions were combined, and the final weight was obtained. First, the data were spatially modelled to model and calculate the local weights. Then Block Statistics spatial filter without overlap was used to determine the neighborhood. The range of local changes, maximum and minimum values, were calculated, and local weights were obtained based on that. Finally, the information layers were descaled. After that, the unscaled criterion layers were multiplied by the national weights and the final national scores were obtained. In the next step, the data of the evaluated information layers (local and national) were transferred to the points of emergency databases. Based on the analysis, the fit was done. Results and discussionGeneral or global weights pay attention to the relative importance of indicators, which is the starting point for calculating local weights. Based on the research results, the most critical indicators are industries, cities and hospitals, which are more important in the location of road emergency stations. However, in order to achieve better results, it is necessary to build a local weight layer. The results of the research show that the indicators' weight and the difference in the criteria (general weight) are not equal in the entire geographical area, and the areas with a larger range of changes have a higher coefficient.Because, unlike general weights that are obtained based on different methods, local weights are estimated based on the principle of sensitivity of the range of changes and are changed spatially, and a fixed value is not considered for all areas. According to the research findings, the highest level in the general and local evaluation method corresponds to 0.5 to 0.7. Based on the local (geographic) weight method, it is less than the national or general method in the range of 0.9 to 1. Furthermore, this is due to the more precise nature of this method, which models the effects of local changes. To evaluate the compliance of the emergency centers with the final maps of suitability assessment, the information on the suitability maps was transferred to the map of the emergency center points of Fars province. Based on the evaluation of 207 emergency stations, according to the general method, 14 percent are in the high group (0.9-1), and according to the local or geographical method (16.9), percent are in this group. ConclusionAt the level of space and geographical regions, phenomena and geographical complications are not uniformly distributed, some phenomena have a homogeneous distribution, and some have a heterogeneous distribution. On the one hand, the phenomena and decision issues are affected by the context in which they are formed and evolve; on the other hand, these phenomena are placed in the network of mutual relations. Furthermore, the results of the set of phenomena may differ from the results of the phenomena individually and separately; in this article, an attempt has been made to address the issue that in spatial analysis and planning, it is necessary to pay attention to geographical differences in decision-making. Furthermore, it should not be evaluated in general terms of spatial decision problems; one of the methods of modelling these differences and spatial changes is to consider the local weight of the criteria. Based on the research findings, local (geographical) and national analysis results are different and can better show these changes. On the other hand, the pattern of spatial differences also has its spatial pattern, and paying attention to these differences in spatial differences can be the subject of further studies. FundingThere is no funding support. Authors’ ContributionAuthors contributed equally to the conceptualization and writing of the article. All of the authors approved the content of the manuscript and agreed on all aspects of the work declaration of competing interest none. Conflict of InterestAuthors declared no conflict of interest. Acknowledgments We are grateful to all the scientific consultants of this paper.

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نویسندگان: 

NAJAFI F. | ZARE K.

اطلاعات دوره: 
  • سال: 

    2016
  • دوره: 

    6
  • شماره: 

    1
  • صفحات: 

    57-63
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    50
  • دانلود: 

    0
چکیده: 

The combination of a carbon nanotube and Methotrexate (an ordinary form of anticancer drug) was investigated based on the Hartree–Fock theory calculations in the gas phase, water and ethanol environment. Thermodynamic functions including Gibbs free energy, entropy, enthalpy changes were computed at different temperatures. We found a relation between dipole moment of the solute and dielectric constant of the solvent. The Gibbs free energy of solvation is reduced by increasing the dielectric constant of solvents.

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